Introduzzjoni: Skont l-Organizzazzjoni Dinjija tas-Saħħa, aktar minn 2 miljun mara madwar id-dinja jiġu djanjostikati bil-kanċer tas-sider kull sena. Huwa l-aktar kanċer prevalenti fin-nisa fid-dinja, u joqtol kważi 700,000 persuna kull sena.
Madwar 40 fil-mija tan-nies iddijanjostikati bil-marda jispiċċaw ikollhom jagħmlu mastektomija, li tinvolvi t-tneħħija parzjali jew kompleta tat-tessut tas-sider affettwat. Madankollu, bi trattamenti moderni, ir-rata ta 'sopravivenza hija aktar minn 90 fil-mija, li jfisser li aktar u aktar nisa qed ifittxu trattamenti ta' rikostruzzjoni tas-sider biex jissostitwixxu t-tessut mitluf.
△Bioprinted breast implants contain patient cells to improve transplant success, image via Healshape
French Healshape tirċievi 6.8 miljun f'finanzjament tas-Serje A
Fit-23 ta 'Jannar 2022, Antarctic Bear sar jaf li Healshape, startup Franċiża ta' mediċina riġenerattiva, ġabret 6.8 miljun (madwar 43 miljun wan) f'finanzjament tas-Serje A biex tiżviluppa impjanti tas-sider bioprinted 3D bl-użu ta 'ċelluli ħajjin tal-pazjent.
Il-kumpanija, appoġġjata mill-aċċeleratur tat-trasferiment tat-teknoloġija Pulsalys SAS, irċeviet aktar minn miljun f'fondi u sussidji pro bono minn Franza mit-tnedija tagħha f'Jannar 2020.
Healshape's mission is to provide specific 3D bioprinted breast prostheses for breast cancer patients undergoing mastectomy. These implants can be printed in virtually any shape and size and can help rebuild breasts and nipples without the risk of implant rejection.
Sophie Brac de la Perrière, CEO of Healshape, said: "Female patients will have their breasts restored within 6 to 9 months, with no trace of a bioprosthesis. This will help patients accept their own image and recreate their own body. Satisfied."
△Healshape scientists 3D bioprinted custom breast implants, photo from Healshape
Preċedentement, kirurġija ta 'rikostruzzjoni tas-sider tipikament użat impjanti artifiċjali, jew matriċi ta' tessuti rotob minn bnedmin u annimali oħra. Impjanti minn dawn is-sorsi huma dejjem f'riskju ta 'reazzjoni immuni li tista' tittardja l-proċess ta 'fejqan.
Healshape's tissue engineering approach addresses these issues by combining 3D bioprinting technology with live cell cultures taken from the patient's own body.
Impjanti tas-sider assorbabbli bioprinted
Healshape's bioprosthetic technology relies on an absorbable hydrogel that can be 3D bioprinted into any freeform shape. Once implanted in the human body, fat transfer from the patient's own body cells facilitates the colonization of the breast implant and allows it to develop into natural breast tissue, while all of this hydrogel is gradually absorbed and replaced.
Healshape's technology is the result of a bioprinting study in collaboration with a research group led by Christophe Marquette, a senior researcher at the Institute for Molecular and Supramolecular Research at the French National Centre for Scientific Research (ICBMS). Marquette also leads the 3d.FAB platform and founded the tissue engineering company LabSkin Creations. Healshape's bioink technology is currently patent protected.
Marquette added: "Originally, the technology was developed for printing skin substitutes. For the Healshape project, it was necessary to adapt the process to print volumes and ensure subsequent consolidation of the bioink to make it compatible for implantation in vivo" .
Healshape's 3D bioprinting technology is currently in the preclinical stage, with clinical trials expected to begin within the next two years.
Progress tar-riċerka tal-proteżi tas-sider tal-istampar 3D globali
Fl-2016, Zhang Xue (psewdonimu), li sofra minn kanċer tas-sider, ġie kkurat fl-Isptar Xijing. F'dak iż-żmien, id-daqs tat-tumur qabeż is-6 ċm, u minkejja l-kimoterapija neoadjuvanti, saret biss mastektomija totali. L-esperti ddeċidew li jagħmlu kirurġija ta' rikostruzzjoni tas-sider b'istampar 4D megħjun mill-kompjuter ta' fillers ta' materjal bijodegradabbli.
Qabel l-operazzjoni, saret skannjar tal-MRI tas-sider-irqiq mit-tim mid-Dipartiment tar-Radjoloġija, l-Isptar Xijing. It-tim kirurġiku ġabar b'mod preċiż informazzjoni dwar l-immaġni tat-tumur u tas-sider permezz tal-MRI, u wettaq rikostruzzjoni 3D u risezzjoni simulata fuq il-kompjuter. Fuq din il-bażi, id-daqs tal-mili huwa ddisinjat b'mod preċiż skont id-difett tat-tessut simulat, u s-sit tad-difett huwa stampat 3D wieħed-għal-wieħed.
△ 4D printed biodegradable material filler
Dakinhar tal-operazzjoni, id-direttur Ling Rui u l-professur assoċjat Zhang Juliang tad-Dipartiment tal-Kirurġija Vaskulari tas-Sider tal-Isptar Xijing wettqu qtugħ estensiv ta 'kanċer tas-sider tax-xellug u dissezzjoni tal-lymph node axillari bbażata fuq ir-riżultati ta' simulazzjoni tal-kompjuter. Filler ta' materjal bijodegradabbli stampat 4D-inġinerija minn qabel għal rikostruzzjoni tas-sider b'suċċess. Il-pazjent irkupra sew wara l-operazzjoni u ngħata l-ħruġ fit-tielet jum. Il-pazjent irċieva wkoll radjuterapija bħala rutina wara l-operazzjoni. Wara diversi ri-eżamijiet, l-impjanti ġew iffurmati gradwalment, u kellhom kompatibilità tajba tat-tessuti, u t-tessut fibrovaskulari awtologu beda jikber.
Fl-2018, żewġ studenti tal-Università ta' Plymouth Rosie Brave u Sam Jackman iddisinjaw sider falz roża stampat 3D-li se jibdel il-ħajja ta' dawk li ssalvaw il-kanċer tas-sider.
Brave was inspired by Jackman's mother, who had had surgery and had traditional breast implants installed, but was confused by the "sweaty" and "uncomfortable" breast implants.
Allura Brave u Jackman ħarġu biex jerġgħu jaħsbu kompletament id-disinn tal-impjant tas-sider u joħorġu b’disinji li jġibu ferħ lil min jilbisha. Il-mudelli stampati 3D li joħolqu huma ikkuluriti, ħfief u nifs, u ddisinjati ma’ dawk li esperjenzaw it-trawma tal-kanċer tas-sider u l-mastektomija.
Fl-2019, myReflection tal-bidu mediku bbażat-New Zealand-uża skans 3D u forom stampati 3D biex tiżviluppa impjanti tas-sider personalizzati għal pazjenti bil-kanċer wara mastektomija.
Il-proteżi tuża teknoloġija ta 'skannjar 3D biex tiddetermina d-dimensjonijiet esterni, u hija ddisinjata b'qalba ta' ġewwa u materjal tas-silikonju ċertifikat ISO-fuq barra.
△Customized breast prosthesis made with 3D printing mold, picture from myReflection
Fl-2021, l-istartjar tal-bijoteknoloġija bbażata fil-Korea t'Isfel-Plcoskin ħabbret li se tmexxi proġett ta' riċerka konġunta internazzjonali ffukat fuq l-iżvilupp ta' tip ġdid ta' impjanti tas-sider stampati 3D. Flimkien ma' Yonsei University u LipoCoat, kumpanija tal-kisi ta' apparat mediku bbażata fl-Olanda-, Plcoskin se tirċievi madwar 2 biljun won (1.7 miljun) f'finanzjament fit-tliet snin li ġejjin.
Fl-2021, il-manifattur tal-printer 3D 3D Systems reċentement ħabbar ftehim ta' ko-iżvilupp mal-kumpanija tal-mediċina riġenerattiva CollPlant biex tiżviluppa strutturi ta 'tessut artab bijoprinted 3D għal trattamenti ta' rikostruzzjoni tas-sider. Strutturi tat-tessut artab se jintużaw biex jipprovdu appoġġ lill-parti t'isfel tas-sider u jżidu l-kopertura ġenerali tal-impjant. Bħal Healshape, l-għan aħħari huwa li jittejjeb is-suċċess tal-kirurġija ta 'rikostruzzjoni tas-sider għal superstiti tal-kanċer.